Thiazole and oxazole-substituted arylamides

Details Thiazole and oxazole-substituted arylamides Thiazole and oxazole-substituted arylamides

C - Chemistry, Metallurgy

07

D

C07D 263/32 (2006.01) A61K 31/19 (2006.01) A61P 13/00 (2006.01) C07D 277/30 (2006.01) C07D 277/66 (2006.01) C07D 401/14 (2006.01)

Patent

CA 2668399

Compounds of the formula (I) or a pharmaceutically acceptable salt thereof, wherein: R1 is a group of formula A or formula B; and X, R2, R3, R4, R5, R6, Ra and Rb are as defined herein. Also provided are methods of using the compounds for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist and methods of making the subject compounds.

Composés représentés par la formule (I) ou des sels de qualité pharmaceutique de ces composés. Dans cette formule, R1 est un groupe de formule A ou B, et X, R2, R3, R4, R5, R6, Ra and Rbsont comme définis dans le descriptif. Sont également décrites des méthodes d'utilisation de ces composés pour le traitement de maladies induites par un antagoniste du récepteur P2X3 et ou PX2/3 et des procédés de fabrication de ces composés.

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