Method of making oil filled paucilamellar lipid vesicles

Details Method of making oil filled paucilamellar lipid vesicles Method of making oil filled paucilamellar lipid vesicles

B - Operations, Transporting

01

J

B01J 13/02 (2006.01) A61K 9/127 (2006.01) A61K 9/50 (2006.01) B01F 17/42 (2006.01)

Patent

CA 2093526

A new "cold-loading" technique for filling the amorphous central cavity of paucilamellar lipid vesicles with a water immis- cible material has been developed. Preformed, substantially aqueous filled paucilamellar lipid vesicles are mixed with the water immiscible material to be encapsulated under intermediate mixing conditions, thereby replacing the aqueous solution with the water-immiscible solution. The "cold-loading" technique is particulary useful for encapsulation of volatiles and heat labile mate- rials.

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