C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A61K 38/17 (2006.01) C07K 1/107 (2006.01) C07K 1/113 (2006.01) C07K 14/705 (2006.01) C07K 14/725 (2006.01) C12N 1/21 (2006.01) C12N 15/12 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2144319
The present invention relates to recombinantly-produced CTLA4 polypeptides having B7 binding activity that are not the product of a fusion between CTLA4 and human Ig genes. The CTLA4 polypeptides of the present invention generally contain an amino acid sequence corresponding to the extracellular domain of the CTLA4 receptor protein. The invention further provides functional derivatives of the CTLA4 polypeptides, including muteins and conjugates containing polyethylene glycol. Methods for preparing the recombinant CTLA4 polypeptides are also provided, as well as methods for separating the monomeric and dimeric forms of the recombinant polypeptides as well as active and less active dimer forms.
La présente invention porte sur des polypeptides CTLA4 produits par recombinaison et conservant une activité de liaison B7, sans pour autant résulter de la fusion entre le CTLA4 et les gènes Ig humains. Les polypeptides CTLA4 de la présente invention comportent généralement une séquence d'acide aminé correspondant au domaine extra-cellulaire de la protéine réceptrice du CTLA4. En outre, l'invention concerne des dérivés fonctionnels des polypeptides CTLA4, y compris des mutéines et des conjugués contenant du polyéthylène glycol. L'invention porte également sur la préparation des polypeptides CTLA4 recombinants et sur les procédés de séparation des formes monomères et dimères des polypeptides recombinants ainsi que les formes des dimères actives et moins actives.
Cox George N.
Pratt Dickson G.
Amgen Boulder Inc.
Gowling Lafleur Henderson Llp
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