Prmts as modifiers of the p53 pathway and methods of use

Details Prmts as modifiers of the p53 pathway and methods of use Prmts as modifiers of the p53 pathway and methods of use

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A61K 31/7088 (2006.01) A61K 38/00 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C12Q 1/00 (2006.01) C12Q 1/02 (2006.01) C12Q 1/42 (2006.01) C12Q 1/48 (2006.01) C12Q 1/527 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/573 (2006.01) G01N 33/574 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2449281

Human PRMT genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of PRMT are provided.

L'invention concerne des gènes PRMT humains identifiés comme modulateurs de la voie p53, ces gènes étant donc des cibles thérapeutiques pour des troubles associés à la fonction p53 défectueuse. Cette invention a également trait à des méthodes d'identification de modulateurs de p53 consistant à cribler des agents qui modulent l'activité de PRMT.

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