Processing crude iodixanol mixture by nanofiltration

Details Processing crude iodixanol mixture by nanofiltration Processing crude iodixanol mixture by nanofiltration

C - Chemistry, Metallurgy

07

C

C07C 231/12 (2006.01) B01D 61/00 (2006.01) C07C 231/22 (2006.01) C07C 237/46 (2006.01)

Patent

CA 2710489

This invention relates generally to industrial preparation of iodixanol (1,3- bis(acetamido)-N,N'-bis[3, 5-bis(2,3 -dihydroxypropylaminocarbonyl)-2,4,6- triiodophenyl]-2- hydroxypropane), a non-ionic X-ray contrasting agent. It further relates to a method for preparing a crude mixture of the dimerisation reaction from 5-acetamido-N,N'- bis(2,3- dihydroxypropyl)-2,4,6-triiodoisophthalamide ("Compound A") to iodixanol for the crystallization of iodixanol. In particular, it relates to an industrial procedure of simultaneously reducing the salt content and the alcoholic dimerisation solvent using a nanofiltration system prior to the crystallization of iodixanol.

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