Devices and compounds for treating arterial restenosis

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/155 (2006.01) A61K 31/198 (2006.01) A61L 24/10 (2006.01) A61L 31/16 (2006.01) A61K 9/00 (2006.01)

Patent

CA 2375923

Described herein is the use of ADPRT decoy substrates to treat or prevent proliferative disorders. In one example, MIBG is shown to prevent restenosis in damaged vessels. In one embodiment, MIBG is combined with an adhesive agent for localizing the mixture to the site of injury. As a result of this arrangement, MIBG is not systemically released.

L'invention concerne l'utilisation de substrats leurres d'ADPRT pour traiter ou prévenir des troubles causés par la prolifération. Dans un exemple, on démontre que la méta-iodobenzylguanidine (MIBG) prévient la resténose dans les vaisseaux endommagés. Dans un mode de réalisation, la MIBG est combinée avec un agent adhésif afin de pouvoir localiser le mélange sur le site de la blessure. En conséquence, la MIBG n'est pas libérée de manière systémique.

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