C - Chemistry – Metallurgy – 07 – J
Patent
C - Chemistry, Metallurgy
07
J
C07J 1/00 (2006.01) C07J 41/00 (2006.01)
Patent
CA 2183005
An estradiol derivative-chlorambucil conjugate of the formula (II) Image (II) wherein R1 is alkyl or alkoxyl of 1 to 4 carbon atoms; R2 is acyl, dansyl, or alkyl; R3, R4, and R5 independently are H, oxo, OH, or acyloxy; m is an integer of 1 to 3; n is an integer of 0 to 3; and X is halogen, OH, or a salt thereof; provided that when n is 0, all of R3, R4, and R5 are not H at the same time, and at least one of R3, R4, and R5 is a group other than H and OH; and further, when n is 2 or 3, the groups R1 are the same or different; a process for preparing the same, and a pharmaceutical composition containing the conjugate are described.
Asano Kiro
Matsudaira Tadahiro
Mitsuhashi Satoshi
Saito Tsuyoshi
Tamura Fumio
Kureha Chemical Industry Co. Ltd.
Mcfadden Fincham
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