Methods of treating cerebral ischemia

A - Human Necessities – 61 – K

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A61K 38/08 (2006.01) A61K 31/405 (2006.01) A61K 38/10 (2006.01)

Patent

CA 2507668

The present invention provides methods of treating cerebral ischemia in mammals comprising inducing hypothermia in a mammal before, during, or following cerebral ischemia in the mammal. The hypothermia is induced by administering to the mammal an effective dose of a neurotensin analog that is capable of crossing the blood-brain barrier and the comprises neo-tryptophan.

L'invention concerne des procédés relatifs au traitement de l'accident ischémique transitoire chez les mammifères, qui consistent à induire une hypothermie avant, pendant ou après l'accident en question chez le mammifère concerné. A cet effet, on administre au mammifère une dose efficace d'analogue de neurotensine capable de traverser la barrière hémato-encéphalique et renfermant un néo-tryptophane.

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