Selenophene anti-tumor agents

Details Selenophene anti-tumor agents Selenophene anti-tumor agents

C - Chemistry, Metallurgy

07

D

C07D 345/00 (2006.01) A61K 31/33 (2006.01) A61K 31/34 (2006.01) A61K 31/38 (2006.01) A61K 31/40 (2006.01) A61K 31/715 (2006.01) C07D 207/333 (2006.01) C07D 307/46 (2006.01) C07D 307/52 (2006.01) C07D 333/22 (2006.01) C07D 421/06 (2006.01) C07D 421/14 (2006.01) C08B 37/16 (2006.01)

Patent

CA 2255664

Novel selenophene compounds useful as anti-tumor agents are described. Preferred compounds include compounds of formula I: (see formula I) wherein R1 and R2 are independently selected from the group consisting of; (see formula II, III) H, CHO, CH2OH and CH2NH2; and X and Y are independently selected from the group consisting of Se, S, O, NCH3 and NH. Pharmaceutical compositions and a method for treating patients having tumors utilizing the disclosed selenophene compounds are also described.

L'invention concerne de nouveaux composés au sélénophène, destinés à être utilisés comme agents anti-tumoraux. De préférence, les composés sont représentés par la formule (I). Dans ladite formule, R1 et R2 sont choisis indépendamment dans le groupe comprenant (a) et (b), H, CHO, CH2OH et CH2NH2; X et Y sont choisis indépendamment dans le groupe comprenant Se, S, O, NCH3 et NH. On décrit par ailleurs des compositions pharmaceutiques et un procédé de traitement, à l'aide des composés considérés, des patients qui sont atteints de tumeurs.

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