C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/605 (2006.01)
Patent
CA 2396920
Disclosed is a method of preparing a GLP-1 compound that is soluble in aqueous solution at pH 7.4 from a GLP-1 compound that is substantially insoluble in aqueous solution at pH 7.4. The insoluble GLP-1 compound is dissolved in aqueous base or in aqueous acid to form a GLP-1 solution. The GLP-1 solution is then neutralized to a pH at which substantially no amino acid racemization of the GLP-1 compounds occurs, after which the soluble GLP-1 compound is isolated from the neutralized solution.
Cette invention concerne une méthode de préparation d'un composé GLP-1 qui soit soluble dans une solution aqueuse à un pH de 7,4 à partir d'un composé GLP-1 sensiblement insoluble dans une solution aqueuse au pH de 7,4. Dissous dans une base aqueuse ou dans un acide aqueux, le composé GLP-1 insoluble forme une solution GLP-1. La solution GLP-1 est alors neutralisée à un niveau de pH auquel ne se produit pratiquement aucune racémisation des acides aminés pour les composés GLP-1, à la suite de quoi le composé GLP-1 soluble est isolée de la solution neutralisée.
Prouty Walter Francis Junior
Rinella Joseph Vincent Junior
Eli Lilly And Company
Gowling Lafleur Henderson Llp
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