Methods for assessing, improving, or maintaining urogenital...

A - Human Necessities – 61 – B

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A61B 5/00 (2006.01) A61B 1/303 (2006.01) G01N 33/74 (2006.01)

Patent

CA 2541348

This invention relates to methods and kits useful for improving or maintaining urogenital health using an estrogen agonist/antagonist. The methods of treatment are effective for improving or maintaining urogenital health while substantially reducing the concomitant liability of adverse effects associated with estrogen administration. This invention also relates to methods of assessing vaginal health. Preferred estrogen agonists/antagonists are of the formula (I): (see figure I) wherein A is CH2 or NR; B, D and E are CH or N; Y is an optionally substituted carbocyclic or heterocyclic group; Z1 is a hydrocarbon spacer optionally interrupted by a heteroatom; G is an amine group; R is H or alkyl; and a is 0, 1 or 2.

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