Use of nucleic acids containing unmethylated cpg...

Details Use of nucleic acids containing unmethylated cpg... Use of nucleic acids containing unmethylated cpg...

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 31/70 (2006.01) C07H 21/00 (2006.01)

Patent

CA 2281838

The present invention is based on the finding that nucleic acids containing at least one unmethylated cytosine-guanine (CpG) dinucleotide affect immune responses in a subject. These nucleic acids containing at least one unmethylated cytosine-guanine (CpG) dinucleotide can be used to treat pulmonary disorders having an immunologic component, such as a response to inhaled lipopolysaccharide. The invention provides methods of treating subjects who have or are at risk of having these pulmonary disorders, and methods of altering the immunological components of the pulmonary disorders. The invention also provides pharmaceutical compositions for treating pulmonary disorders that have an immunologic component.

Cette invention se fonde sur la découverte selon laquelle les acides nucléiques contenant au moins un dinucléotide cytosine-guanine (CpG) non méthylé affectent les réponses immunitaires d'un sujet. Ces acides nucléiques contenant au moins un dinucléotide cytosine-guanine (CpG) non méthylé peuvent être utilisés pour traiter les troubles pulmonaires ayant une composante immunologique, telle que les réactions à l'inhalation de lipopolysaccharides. Cette invention présente des procédés pour traiter des sujets qui souffrent de tels troubles pulmonaires ou qui sont exposés au risque d'être atteints de tels troubles pulmonaires, ainsi que des procédés pour modifier les composantes immunologiques de ces troubles pulmonaires. Cette invention présente également des compositions pharmaceutiques pour traiter les troubles pulmonaires ayant une composante immunologique.

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