Ilk inhibitors for the treatment of renal disease

Details Ilk inhibitors for the treatment of renal disease Ilk inhibitors for the treatment of renal disease

A - Human Necessities

61

K

A61K 31/415 (2006.01) A61K 38/00 (2006.01) A61K 38/02 (2006.01) A61K 38/55 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) A61K 49/00 (2006.01) A61P 13/12 (2006.01) C07K 16/18 (2006.01)

Patent

CA 2468496

The invention relates to the treatment of renal diseases using modulators of integrin linked kinase. Methods of treatment as well as therapeutic agents including antisense, small molecules, catalytic peptides and antibodies are disclosed. The agents of the invention may also be used in combination with traditional therapies for renal disease including ACE inhibitors. An advantage of the invention is that it treats one of the causes of renal disease, rather than just ameliorating symptoms, and can help prevent the progression of renal disease to the point of acute renal failure.

Cette invention porte sur le traitement de maladies du rein faisant intervenir des modulateurs de la kinase liée à l'intégrine. Cette invention concerne des méthodes de traitement ainsi que des agents thérapeutiques tels que les molécules anti-sens, les petites molécules, les peptides catalytiques et les anticorps. Les agents de la présente invention peuvent également être utilisés conjointement avec des thérapies conventionnelles visant à traiter les maladies du rein comprenant des inhibiteurs de l'enzyme convertissant l'angiotensine. Cette invention présente l'avantage de traiter l'une des causes de la maladie du rein plutôt que de juste améliorer ses symptômes, et peut contribuer à empêcher la progression de la maladie du rein jusqu'au stade de l'insuffisance rénale aiguë.

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