C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/12 (2006.01) A01K 67/027 (2006.01) A61K 39/40 (2006.01) C07K 16/00 (2006.01) C07K 16/46 (2006.01) C12N 5/10 (2006.01) C12N 5/20 (2006.01) C12N 15/13 (2006.01) C12N 15/63 (2006.01) G01N 33/569 (2006.01) G01N 33/577 (2006.01)
Patent
CA 2548015
The invention described herein provides for human antibodies produced in non- human animals that specifically bind to lipopolysaccharide (LPS) from strains Fisher Devlin (International Serogroups) It-2 (011), It-3 (02), It-4 (01), It- 5 (010), It-6 (07), PA01 (05), 170003 (02), IATS016 (02/05), and 170006 (02). The invention further provides methods for making the antibodies in a non- human animal, expression of the antibodies in cell lines including hybridomas and recombinant host cell systems. Also provided are kits and pharmaceutical compositions comprising the antibodies and methods of treating or preventing pseudomonas infection by administering to a patient the pharmaceutical compositions described herein.
L'invention concerne des anticorps humains produits dans des animaux non humains, qui se lient de manière spécifique à un lipopolysaccharide (LPS) de souches Fisher Devlin (sérogroupes internationaux ) It-2 (011), It-3 (02), It-4 (01), It-5 (010), It-6 (07), PA01 (05), 170003 (02), IATS016 (02/05) et 170006 (02). Cette invention concerne également des procédés de production d'anticorps dans un animal non humain, l'expression de ces anticorps dans des lignées cellulaires comprenant des hybridomes et des systèmes de cellules hôtes de recombinaison. La présente invention concerne en outre des nécessaires et des compositions pharmaceutiques comprenant des anticorps, ainsi que des procédés pour traiter ou prévenir des infections par Pseudomonas, par administration desdites compositions pharmaceutiques à un patient.
Schreiber John R.
Smart & Biggar
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