Modulation of glucagon receptor expression

C - Chemistry – Metallurgy – 12 – N

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C12N 15/11 (2006.01) A61K 31/712 (2006.01)

Patent

CA 2623762

Compounds, compositions and methods are provided for modulating the expression of glucagon receptor. The compositions comprise antisense compounds, particularly antisense oligonucleotides which have particular in vivo properties, targeted to nucleic acids encoding glucagon receptor. Methods of using these compounds for modulation of glucagon receptor expression and for treatment of diseases are provided.

L'invention concerne des composés, des compositions et des méthodes de modulation de l'expression du récepteur du glucagon. Les compositions comprennent des composés antisens, en particulier des oligonucléotides antisens présentant des propriétés spécifiques in vivo, ciblés sur des acides nucléique codant pour le récepteur du glucagon. L'invention concerne également des méthodes d'utilisation desdits composés dans la modulation de l'expression du récepteur du glucagon et dans le traitement de maladies.

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