Substituted 1, 3, 5-triazines and pyrimidines as abca-1...

Details Substituted 1, 3, 5-triazines and pyrimidines as abca-1... Substituted 1, 3, 5-triazines and pyrimidines as abca-1...

C - Chemistry, Metallurgy

07

D

C07D 239/48 (2006.01) A61K 31/505 (2006.01) A61K 31/53 (2006.01) A61K 45/06 (2006.01) A61P 9/10 (2006.01) C07C 237/06 (2006.01) C07C 237/22 (2006.01) C07C 237/40 (2006.01) C07C 275/26 (2006.01) C07C 311/20 (2006.01) C07C 323/36 (2006.01) C07C 323/40 (2006.01) C07C 323/60 (2006.01) C07C 327/42 (2006.01) C07C 327/48 (2006.01) C07D 251/16 (2006.01) C07D 251/20 (2006.01) C07D 251/46 (2006.01) C07D 251/52 (2006.01) C07D 319/08 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 409/1

Patent

CA 2430951

The present invention provides compounds that elevate cellular expression of the ABCA-1 gene, promoting cholesterol efflux from cells and increasing HDL levels in the plasma of a mammal, in particular humans. The compounds are useful for treating coronary artery disease.

La présente invention concerne des composés qui augmentent l'expression cellulaire du gène ABCA-1 en facilitant la sortie du cholestérol de cellules et en augmentant les taux de HDL dans le plasma d'un mammifère, en particulier un humain. Les composés de l'invention sont utiles pour le traitement d'une coronaropathie.

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