Genetic therapy of diseases of the central nervous system...

Details Genetic therapy of diseases of the central nervous system... Genetic therapy of diseases of the central nervous system...

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 31/70 (2006.01) A61K 47/42 (2006.01) C12N 15/85 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2198474

A DNA sequence is disclosed for the genetic therapy of diseases of the central nervous system. The essential components of the DNA sequence are the activator sequence, the promoter module and the active substance coding gene. The activator sequence is specifically activated in activated endothelial or glial cells. Activation is cell cycle-regulated by the promoter module. The active substance represents an inhibitor of the nerve growth factor, a dopanine metabolism enzyme and/or a nerve cell protection factor. The disclosed DNA sequence is inserted into a viral or non-viral vector, supplemented with a ligand with affinity for the target cells.

L'invention concerne une séquence d'ADN pour la thérapie génétique de maladies du système nerveux central. Les éléments essentiels de la séquence d'ADN sont la séquence activatrice, le module promoteur et le gène de codage de la substance active. La séquence activatrice est activée spécifiquement dans des cellules endothéliales ou gliales activées. L'activation est régulée en fonction du cycle cellulaire par le module promoteur. La substance active représente un inhibiteur du facteur de croissance des nerfs, une enzyme du métabolisme de la dopanine et/ou un facteur de protection des cellules nerveuses. La séquence d'ADN décrite est insérée dans un vecteur viral ou non viral complété par un ligand ayant une affinité par les cellules cibles.

Affiliated with

Also associated with

Rating

Genetic therapy of diseases of the central nervous system... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Genetic therapy of diseases of the central nervous system..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Genetic therapy of diseases of the central nervous system... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1390634