Therapeutic cholesterol gallstone dissolution method

A - Human Necessities – 61 – K

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167/248, 167/280

A61K 31/21 (2006.01) A61K 31/075 (2006.01) A61K 31/12 (2006.01)

Patent

CA 2033509

(57) Abstract A method and apparatus are disclosed for treating a patient having cholesterol calculi which involves infusing into the bil- ary tract of said patient a C5-C6 ester, ether or ketone having a boiling point in the range of 80°-140° C or a mixture thereof m an amount and at a flow rate effective to at least partially dissolve said calculi rapidly. The invention also encompasses dissolving cholesterol calculi by exposing such calculi to contact with effective quantities or those solvent compounds. The apparatus includes a high flow rate catheter pumping system for infusing a gallstone dissolution solvent into the gallbladder of a patient and aspiring the gallstone dissolution solvent from the gallbladder, and a unit measure container of the sol- vent. The preferred esters, ethers and ketones are n-propyl acetate, isopropyl acetate, ethyl propionate, ethyl isobutyrate, cyclopentanone, pentanone and methyl l-amyl ether. Contact flow rates are sufficiently high to insure fluid turbulence in the biliary tract region surrounding the calculi.

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