Pharmaceutical combinations for the treatment of...

Details Pharmaceutical combinations for the treatment of... Pharmaceutical combinations for the treatment of...

A - Human Necessities

61

K

A61K 45/08 (2006.01) A61K 31/198 (2006.01) A61K 31/44 (2006.01) A61K 31/4418 (2006.01) A61K 31/495 (2006.01) A61K 38/55 (2006.01) A61K 45/06 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2397371

This invention relates to methods of treating neurodegenerative diseases, comprising administering to a patient in need of such treatment an N-NOS inhibitor in combination with either: (a) NMDA receptor antagonist; (b) a sodium channel antagonist; (c) an acetylcholine esterase inhibitor; (d) a dopamine agonist; (e) a potassium channel opener; (f) an AMPA/kainate receptor antagonist; (g) a calcium channel antagonist; (h) a GABA- A receptor modulator (e.g., a GABA-A receptor agonist); (i) TPA (j) matrix- metalloprotease inhibitor or (k) L-Dopa. The pharmaceutical compounds are also disclosed.

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