Monoclonal antibodies and compositions comprising such...

Details Monoclonal antibodies and compositions comprising such... Monoclonal antibodies and compositions comprising such...

A - Human Necessities

61

K

A61K 39/395 (2006.01)

Patent

CA 2754102

The present invention describes methods for inhibiting angiogenesis in tissues using vitronectin .alpha.v.beta.5 antagonists. The present invention provides monoclonal antibodies, and compositions comprising such, which are useful in the inhibition of .alpha.v.beta.5 mediated angiogenesis. The .alpha.v.beta.5- mediated angiogenesis is correlated with exposure to cytokines including vascular endothelial growth factor, transforming growth factor-.alpha. and epidermal growth factor. Inhibition of .alpha.v.beta.5-mediated angiogenesis is particularly preferred in vascular endothelial ocular neovascular diseases, in tumor growth and in inflammatory conditions, using therapeutic compositions containing .alpha.v.beta.5 antagonists.

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