A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/717 (2006.01) A61P 25/00 (2006.01) A61P 25/28 (2006.01)
Patent
CA 2649272
Disclosed is a pharmaceutical composition having a prophylactic or therapeutic effect on a conformational disease such as Alzheimer's disease, prion disease and amyloidosis. The pharmaceutical composition comprises, as an active ingredient, at least one cellulose ether selected from a cellulose ether having a constitutional unit represented by the general formula (1) shown below, an alkali metal salt of the cellulose ether, an aliphatic acid ester of the cellulose ether, and a mixture thereof. (1) wherein at least one of R's is selected from CH3, C2H5, CH2CH2OH, CH2CH(OH)CH3 and CH2COOM, and the others are independently represent H; and M is selected from H, Na, K and Ca.
La présente invention concerne une composition pharmaceutique ayant un effet prophylactique ou thérapeutique sur une maladie conformationnelle telle que la maladie d'Alzheimer, les maladies à prion ou l'amyloïdose. La composition pharmaceutique comprend, en tant que matière active, au moins un éther de cellulose choisi parmi un éther de cellulose ayant une unité constitutionnelle répondant à la formule générale (1) représentée ci-dessous, un sel de métal alcalin de l'éther de cellulose, un ester d'acide aliphatique de l'éther de cellulose et un mélange de ces corps. (1) dans laquelle au moins un des R est choisi parmi CH3, C2H5, CH2CH2OH, CH2CH(OH)CH3 et CH2COOM et les autres représentent indépendamment H ; et M est choisi parmi H, Na, K et Ca.
Itoham Foods Inc.
Kirby Eades Gale Baker
National University Corporation Tohoku University
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