Glycine transport inhibitors

Details Glycine transport inhibitors Glycine transport inhibitors

A - Human Necessities

61

K

A61K 31/445 (2006.01) A61K 31/00 (2006.01) A61K 31/495 (2006.01) C07D 211/58 (2006.01) C07D 221/00 (2006.01) C07D 235/00 (2006.01) C07D 239/00 (2006.01) C07D 333/22 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2322164

The present invention is concerned with the use of glycine transport inhibiting [4,4-bis(4-fluorophenyl)butyl]-1-(piperazinyl and piperidinyl) derivatives for the preparation of medicaments for treating disorders of the central and peripheral nervous system, in particular psychoses, pain, epilepsy, neurodegenerative diseases (Alzheimer's disease), stroke, head trauma, multiple sclerosis and the like. The invention further comprises novel compounds, their preparation and their pharmaceutical forms.

La présente invention concerne l'utilisation des dérivés [4,4-bis(4-fluorophényl)butyl]-1-(pipérazinyles et pipéridyniles), inhibiteurs du transport de la glycine, pour la préparation de médicaments destinés aux traitements des troubles du système nerveux périphérique et du système nerveux central, en particulier, des psychoses, de la douleur, de l'épilepsie, des maladies neurodégénératives (maladie d'Alzheimer), de l'ictus, du trauma crânien, de la sclérose multiple et des troubles de même genre. La présente invention concerne aussi de nouveaux composés, leur préparation et leurs formes galéniques.

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