Process for the production of 5-chloroxindole

Details Process for the production of 5-chloroxindole Process for the production of 5-chloroxindole

C - Chemistry, Metallurgy

07

D

C07D 209/34 (2006.01) C07C 201/12 (2006.01) C07C 205/58 (2006.01)

Patent

CA 2096043

ABSTRACT OF THE DISCLOSURE A process for the production of 5-chloroxindole from chloronitrobenzene. In a first step, chloronitrobenzene of the formula: Image II is converted with a chloroacetic acid alkyl ester of the general formula: Image III in the presence of a base to produce a chloronitrobenzene acetic acid alkyl ester of the general formula: Image IV The latter is catalytically hydrogenated in a second step with hydrogen to produce the corresponding amine of the general formula: Image V The latter is then cyclized in a third step in the presence of an acid to produce 5-chloroxindole according to the formula: Image , I

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