Tetrahydroimidazo [2,1-a] isoquinoline derivatives

Details Tetrahydroimidazo [2,1-a] isoquinoline derivatives Tetrahydroimidazo [2,1-a] isoquinoline derivatives

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/47 (2006.01) A61K 31/505 (2006.01)

Patent

CA 2241469

The present invention relates to certain tetrahydroimidazo[2,1-a]isoquinoline derivatives according to formula I Image wherein X is a group (A) or (B) Image R1, R2 and R3, which may be the same or different, each represent one or more substituents selected from hydrogen, C1-6alkyl, C3-6cycloalkyl C1-6alkoxy, C1-6alkylthio, C4-6cycloalkenyl, C2-6alkenyl, C2-6alkynyl and halogen; R4, R5, R6 and R7, which may be the same or different, are each selected from hydrogen, C1-6alkoxyC1-6alkyl, C4-6cycloalkenyl, C2-6alkenyl, C2-6alkynyl, C3-6cycloalkyl and C1-6alkyl; n is 1 or 2; or a pharmaceutically acceptable salt or solvate thereof, to processes for their preparation, to pharmaceutical formulations containing them and to their use in medical therapy, particularly in the treatment of depression.

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