Process for the reductive amination of aldehydes and ketones

Details Process for the reductive amination of aldehydes and ketones Process for the reductive amination of aldehydes and ketones

C - Chemistry, Metallurgy

07

C

C07C 209/26 (2006.01)

Patent

CA 2672677

Aldehyde or ketone compounds having more than one carbonyl group are reductively aminated to form a product amine compound having more than one primary amino group. The aldehyde or ketone compound is reacted with the product amine compound in the presence of an alcohol solvent, to form a reaction mixture that contains one or more intermediates. The intermediate is then reductively aminated to form the desired product. This process may produce the desired product in very high yields with low levels of secondary amine impurities.

Des composés aldéhydiques ou cétoniques présentant plus d'un groupe carbonyle sont soumis à une amination réductrice pour former un composé amine produit présentant plus d'un groupe amine primaire. Le composé aldéhydique ou cétonique est mis en réaction avec le composé amine produit en présence d'un solvant alcoolique pour former un mélange réactionnel contenant un ou plusieurs intermédiaires. L'intermédiaire est ensuite soumis à une amination réductrice de manière à former le produit souhaité. Le procédé permet d'obtenir le produit souhaité avec de très hauts rendements et de faibles niveaux d'impuretés amine secondaire.

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