Wnt-7b-like polypeptides and nucleic acids encoding same

Details Wnt-7b-like polypeptides and nucleic acids encoding same Wnt-7b-like polypeptides and nucleic acids encoding same

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 31/7088 (2006.01) A61K 38/18 (2006.01) A61K 39/395 (2006.01) C07K 14/475 (2006.01) C07K 16/22 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2404519

The present invention provides novel isolated Wnt-7B-like polynucleotides and the membrane-associated or secreted polypeptides encoded by the Wnt-7B-like polynucleotides. Also provided are the antibodies that immunospecifically bind to a Wnt-7B-like polypeptide or any derivative, variant, mutant or fragment of the Wnt-7B-like polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the Wnt-7B-like polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states, as well as to other uses.

L'invention concerne de nouveaux polynucléotides isolés de type Wnt-7B, ainsi que les polypeptides associés aux membranes ou sécrétés codés par ces polynucléotides de type Wnt-7B. L'invention concerne aussi les anticorps qui se lient de manière immunospécifique à un polypeptide de type Wnt-7B et tout dérivé, variant, mutant ou fragment du polypeptide, du polynucléotide de type Wnt-7B ou de l'anticorps dirigé contre Wnt-7B. L'invention concerne de plus des procédés dans lesquels le polypeptide, le polynucléotide de type Wnt-7B ou l'anticorps dirigé contre Wnt-7B sont utilisés, entre autres, dans la détection et le traitement d'un large éventail d'états pathologiques.

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