Wild-type measles virus glycoproteins: vaccine and detection...

Details Wild-type measles virus glycoproteins: vaccine and detection... Wild-type measles virus glycoproteins: vaccine and detection...

C - Chemistry, Metallurgy

12

N

C12N 15/45 (2006.01) A61K 39/165 (2006.01) C07K 14/12 (2006.01) C12Q 1/70 (2006.01) G01N 33/569 (2006.01) G01N 33/577 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2133339

WILD-TYPE MEASLES VIRUS GLYCOPROTEINS: VACCINE AND DETECTION METHOD THEREFOR ABSTRACT Amino acid and nucleotide sequences for hemagglutinin and fusion glycoproteins of several wild-type measles strains are provided, and shared amino acid variations in wild-type measles glycoproteins are identified in five wild-type measles viruses. A consensus polypeptide, the amino acid sequence of which reflects variation common to more than one wild-type strain, is the basis for constructing live attenuated vaccines, or recombinant vaccines to replace older, less efficacious vaccines. Immunological reagents useful in differentiating wild-type measles strains from other known strains also can be produced.

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