Triaryl substituted imidazoles and methods of use

Details Triaryl substituted imidazoles and methods of use Triaryl substituted imidazoles and methods of use

A - Human Necessities

61

K

A61K 31/44 (2006.01) A61K 31/4439 (2006.01)

Patent

CA 2271941

2-4-Diaryl-5-pyridylimidazoles are glucagon antagonists. The compounds block the action of glucagon at its receptor. Thus, the compounds can be used in the prophylaxis or treatment of disease states in mammals mediated by elevated levels of glucagon. Examples of such disease states include diabetes, obesity, hypertension, and cachexia and the like.

L'invention concerne des 2,4-Diaryl-5-pyridylimidazoles qui constituent des antagonistes de glucagon. Ces composés bloquent l'action du glucagon sur son récepteur. Ainsi, ces composés peuvent s'utiliser dans la prophylaxie ou le traitement d'affections chez les mammifères se manifestant par des taux élevés de glucagon. Le diabète, l'obésité, l'hypertension, la cachexie et d'autres affections similaires constituent des exemples de telles affections.

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