Preventives/remedies for emotional disorders

Details Preventives/remedies for emotional disorders Preventives/remedies for emotional disorders

A - Human Necessities

61

K

A61K 45/00 (2006.01) A61K 31/4353 (2006.01) A61K 31/4375 (2006.01) A61K 31/4985 (2006.01) A61K 31/551 (2006.01) A61K 31/553 (2006.01) A61P 1/00 (2006.01) A61P 13/02 (2006.01) A61P 25/14 (2006.01) A61P 25/20 (2006.01) A61P 25/24 (2006.01) A61P 43/00 (2006.01) C07D 471/14 (2006.01) C07D 498/04 (2006.01)

Patent

CA 2423364

Preventives/remedies for emotional disorders containing an NK-1 receptor antagonist which has specific characteristics of (1) having no serotonin uptake inhibitory effect, (2) being capable of migrating into the hypothalamus, or (3) having a urinary reflection inhibitory effect; and preventives/remedies for depression accompanied by urinary frequency, urinary incontinence and/or irritable bowel disease, preventives/remedies for mood disorders of patients with urinary frequency and urinary incontinence, and circadian rhythm controllers for hypothalamic endocrine system each containing the NK-1 receptor antagonist.

Cette invention a trait à des agents de prévention et/ou à des médicaments en rapport avec des troubles affectifs, contenant un antagoniste du récepteur de NK-1, lesquels agents ou remèdes se caractérisent, (1), par l'absence d'action inhibitrice de la fixation de sérotonine, (2), par leur capacité à migrer dans l'hypothalamus ou, (3), par leur action inhibitrice de la rétention urinaire. L'invention porte également sur des agents de prévention et/ou sur des remèdes en rapport avec un état dépressif qu'accompagnent de fréquentes mictions, une incontinence urinaire et/ou des syndromes du côlon irritable, ainsi qu'en rapport avec des troubles psychotropes de patients souffrant de fréquence de la miction et d'incontinence d'urine. Cette invention porte, de plus, sur des substances agissant sur le rythme circadien du système endocrinien de l'hypothalamus, contenant, chacune, cet antagoniste du récepteur de NK-1.

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