C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 217/74 (2006.01) C07B 59/00 (2006.01) C07C 215/64 (2006.01) C07D 265/06 (2006.01)
Patent
CA 2680912
Chemical syntheses and medical uses of novel inhibitors of the uptake of monoamine neurotransmitters and pharmaceutically acceptable salts and prodrugs thereof, for the treatment and/or management of psychotropic disorders, anxiety disorder, generalized anxiety disorder, depression, post-traumatic stress disorder, obsessive-compulsive disorder, panic disorder, hot flashes, senile dementia, migraine, hepatopulmonary syndrome, chronic pain, nociceptive pain, neuropathic pain, painful diabetic retinopathy, bipolar depression, obstructive sleep apnea, psychiatric disorders, premenstrual dysphoric disorder, social phobia, social anxiety disorder, urinary incontinence, anorexia, bulimia nervosa, obesity, ischemia, head injury, calcium overload in brain cells, drug dependence, attention deficit hyperactivity disorder, fibromyalgia, irritable bowel syndrome, and/or premature ejaculation are described.
L'invention concerne des synthèses chimiques et des utilisations médicales de nouveaux inhibiteurs du captage des neurotransmetteurs monoamines ainsi que des sels acceptables sur le plan pharmaceutique et des promédicaments de ceux-ci, dans le traitement et/ou la gestion de certains troubles et états tels que: troubles psychotropes, trouble anxieux, trouble d'anxiété généralisée, dépression, trouble de stress post-traumatique, trouble obsessivo-compulsif, trouble panique, bouffées de chaleur, démence, migraine, syndrome hépatopulmonaire, douleur chronique, douleur nociceptive, douleur neuropathique, rétinopathie diabétique douloureuse, dépression bipolaire, apnée obstructive du sommeil, troubles psychiatriques, troubles psychiatriques, trouble distrophique prémenstruel, phobie sociale, trouble d'anxiété sociale, incontinence urinaire, anorexie, boulimie, obésité, ischémie, traumatisme crânien, surcharge calcique dans les cellules du cerveau, pharmacodépendance, hyperactivité avec déficit de l'attention, fibromalgie, syndrome du côlon irritable et/ou éjaculation précoce.
Gant Thomas G.
Sarshar Sepehr
Woo Soon Hyung
Auspex Pharmaceuticals Inc.
Mcfadden Fincham
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