Multivalent t cell receptor complexes

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 47/48 (2006.01) C07K 14/725 (2006.01) C07K 14/82 (2006.01) C07K 19/00 (2006.01) G01N 33/569 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2328144

The present invention relates to a synthetic multivalent T cell receptor complex for binding to an MHC-peptide complex, which multivalent T cell receptor complex comprises a plurality of T cell receptors specific for the MHC-peptide complex. It is preferred that the T cell receptors are refolded recombinant soluble T cell receptors. The synthetic multivalent T cell receptor complex can be used for delivering therapeutic agents or for detecting MHC-peptide complexes, and methods for such uses are also provided.

La présente invention concerne un complexe polyvalent de récepteurs de lymphocytes T destinés à une liaison avec un complexe de peptides du complexe majeur d'histocompatibilité (CMH). En l'occurrence, ce complexe polyvalent de récepteurs de lymphocytes T comprend une pluralité de récepteurs de lymphocytes T spécifiques du complexe peptidique CMH. Les récepteurs de lymphocytes T sont de préférence des récepteurs de lymphocytes T solubles repliés obtenus par recombinaison. Un tel complexe synthétique polyvalent de récepteurs de lymphocytes T convient à l'apport d'agents thérapeutiques ou à la détection de complexes peptidiques CMH. L'invention concerne également des procédés se rapportant à de telles utilisations.

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