Identification and characterization of racemases, definition...

C - Chemistry – Metallurgy – 12 – N

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C12N 9/90 (2006.01) C12Q 1/26 (2006.01) C12Q 1/533 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2515599

This invention relates to the identification and characterization of racemases and definition of protein signatures of these racemases. More particularly, this invention relates to the identification of nucleic acid molecules encoding a peptide consisting of a motif characteristic of the protein signatures, and to the peptides consisting of these motifs and more specifically SEQ ID NOS:1-4. This invention also relates to antibodies specific for the peptides and to immune complexes of these antibodies with the peptides. Further, the invention relates to methods and kits for detecting racemases using the nucleic acid molecules of the invention, as well as the peptides consisting of the motifs and antibodies to these peptides.

L'invention concerne l'identification et la caractérisation de racémases et la définition de signatures protéiques de ces racémases. L'invention porte plus précisément sur l'identification de molécules d'acide nucléique codant pour un peptide consistant en un motif caractéristique des signatures protéiques, et sur des peptides constitués de ces motifs, et plus spécifiquement, les séquences SEQ ID NO :1-4. L'invention se rapporte encore à des anticorps spécifiques des peptides et à des complexes immuns de ces anticorps avec les peptides. Des procédés et des kits de détection de racémases utilisant les molécules d'acide nucléique de l'invention, ainsi que les peptides comprenant les motifs et les anticorps dirigés contre ces peptides sont également décrits.

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