Heterocyclic thioesters and ketones

Details Heterocyclic thioesters and ketones Heterocyclic thioesters and ketones

C - Chemistry, Metallurgy

07

D

C07D 207/08 (2006.01) A61K 31/40 (2006.01) A61K 31/4439 (2006.01) A61K 31/444 (2006.01) A61K 31/445 (2006.01) A61P 25/28 (2006.01) C07D 211/32 (2006.01) C07D 265/30 (2006.01) C07D 277/04 (2006.01) C07D 279/12 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2263927

This invention relates to neurotrophic low molecular weight, small molecule heterocyclic thioesters and ketones having an affinity for FKBP-type immunophilins, and their use as inhibitors of the enzyme activity associated with immunophilin proteins, particularly peptidyl-prolyl isomerase, or rotamase, enzyme activity.

La présente invention se rapporte à des thioesters et des cétones neurotrophiques hétérocycliques à faible poids moléculaire et à petites molécules présentant une affinité envers les immunophilines de type FKBP, et à leur utilisation comme inhibiteurs de l'activité enzymatique associée aux protéines de l'immunophiline, en particulier l'activité enzymatique de la peptidyl-prolyl isomérase ou rotamase.

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