Herpes simplex virus mutants

Details Herpes simplex virus mutants Herpes simplex virus mutants

C - Chemistry, Metallurgy

12

N

C12N 7/04 (2006.01) A61K 39/245 (2006.01) C12N 7/00 (2006.01) C12N 7/01 (2006.01)

Patent

CA 2212706

A herpes simplex virus (HSV) mutant, UL41NHB, is disclosed which is deficient in the virion host shutoff (<u>vhs</u>) function. This mutant is shown to be profoundly attenuated in its ability to replicate at the periphery and in the nervous system, and in its ability to reactivate from latency.

On décrit un mutant du virus de l'herpès dénommé UL41NHB auquel il manque la fonction d'arrêt de l'hôte associée au virion (<u>vhs</u>). Il s'est avéré que l'on atténue ainsi fortement l'aptitu de de ce mutant à la réplication dans les organes périphériques et dans le système nerveux, ainsi que sa réactivation quand il est en phase de latence.

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