C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 413/12 (2006.01) A61K 31/4427 (2006.01) A61P 25/14 (2006.01) A61P 25/16 (2006.01) A61P 25/18 (2006.01) A61P 25/28 (2006.01) C07D 413/14 (2006.01)
Patent
CA 2750678
The present invention is concerned with novel isoxazole derivatives of formula (I), wherein X, R1, R2, R3, R4 and R5 are as described herein, as well as pharmaceutically acceptable salts and esters thereof. The active compounds of the present invention have affinity and selectivity for GABA A .alpha.5 receptor. Further the present invention is concerned with the manufacture of the active compounds of formula I, pharmaceutical compositions containing them and their use as medicaments.
La présente invention porte sur de nouveaux dérivés d'isoxazole de formule (I), dans laquelle X, R1, R2, R3, R4 et R5 sont tels que décrits dans la description, ainsi que sur des sels pharmaceutiquement acceptables et esters de ceux-ci. Les composés actifs de la présente invention ont une affinité et une sélectivité pour le récepteur GABA-A a5. En outre, la présente invention porte sur la fabrication des composés actifs de formule I, sur des compositions pharmaceutiques les contenant et sur leur utilisation comme médicaments.
Jakob-Roetne Roland
Lucas Matthew C.
Thomas Andrew
Borden Ladner Gervais Llp
F. Hoffmann-La Roche Ag
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