A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/18 (2006.01) A61K 9/00 (2006.01) A61L 2/18 (2006.01) A61L 12/14 (2006.01) A61P 27/04 (2006.01) G02C 13/00 (2006.01)
Patent
CA 2272308
The use of low molecular weight amino alcohols in ophthalmic compositions is described. These compounds have been found to enhance the efficacy of anti-microbial preservatives. Particularly preferred amino alcohols are 2-amino-2-methyl-1-propanol (AMP), 2-dimethylamino-2-methyl-1-propanediol (DMAMP), 2-amino-2-ethyl-1,3- propanediol (AEPD), 2-amino-2-methyl-1,3-propanediol (AMPD), and 2-amino-1-butanol (AB). The ophthalmic compositions further optionally comprise a borate/polyol buffer system and an alkylamine.
Cette invention concerne l'utilisation d'amino-alcools de faible poids moléculaire dans des compositions ophtalmiques. Ces composés permettent d'accroître l'efficacité d'agents conservateurs anti-microbiens. Les amino-alcools préférés consistent en du 2-amino-2-méthyl-1-propanol (AMP), en du 2-diméthylamino-2-méthyl-1-propanediol (DMAMP), en du 2-amino-2-éthyl-1,3-propanediol (AEPD), en du 2-amino-2-méthyl-1,3-propanediol (AMPD) et, enfin, en du 2-amino-1-butanol (AB). Ces compositions ophtalmiques peuvent en outre comprendre un éventuel système tampon borate/polyol ainsi qu'un alkylamine.
Alcon Laboratories Inc.
Smart & Biggar
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