N-(indolecarbonyl)piperazine derivatives

Details N-(indolecarbonyl)piperazine derivatives N-(indolecarbonyl)piperazine derivatives

C - Chemistry, Metallurgy

07

D

C07D 209/08 (2006.01) A61K 31/404 (2006.01) A61P 43/00 (2006.01) C07D 209/12 (2006.01) C07D 209/38 (2006.01) C07D 209/42 (2006.01) C07D 209/88 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2383779

Compounds of the formula I (see formula I) in which R1, R2, R4 and R5 have the meanings indicated in Claim 1, are potent 5-HT2A antagonists and are suitable for the treatment of psychoses, schizophrenia, depression, neurological disorders, memory disorders, Parkinson's disease, amyotrophic lateral sclerosis, Alzheimer's disease, Huntington's disease, eating disorders such as bulimia, nervous anorexia, premenstrual syndrome and/or for positively affecting compulsive behaviour (obsessive-compulsive disorder, OCD).

Les composés de la formule (I), dans laquelle R?1¿, R?2¿, R?4¿, et R?5¿ possèdent la signification indiquée dans la revendication 1, sont des antagonistes puissants de 5-HT¿2A?, et conviennent pour le traitement des psychoses, de la schizophrénie, des dépressions, des troubles neurologiques, des troubles de la mémoire, de la maladie de Parkinson, de la sclérose latérale amyotrophe, de la maladie d'Alzheimer, de la maladie d'Huntington, des troubles de l'alimentation tels que la boulimie ou l'anorexie nerveuse, du syndrome prémenstruel et/ou pour influer positivement sur des comportements de type obsessionnels-compulsifs (OCD).

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