Heterocyclic amides

Details Heterocyclic amides Heterocyclic amides

C - Chemistry, Metallurgy

07

D

C07D 213/72 (2006.01) A61K 31/44 (2006.01) A61K 31/535 (2006.01) A61K 31/675 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07F 9/59 (2006.01) C07K 5/06 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2065794

ABSTRACT The present invention relates to certain novel heterocyclic amides which are 1-pyridylacetamide compounds of formula I, set out herein, which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes intermediates useful in the synthesis of these heterocyclic amides, processes for preparing the heterocyclic amides, pharmaceutical compositions containing such heterocyclic amides and methods for their use.

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