Treatment of hematological malignancies with fts and a...

Details Treatment of hematological malignancies with fts and a... Treatment of hematological malignancies with fts and a...

A - Human Necessities

61

K

A61K 31/192 (2006.01) A61P 35/02 (2006.01)

Patent

CA 2648518

Disclosed are methods of treating a hematological malignancy by administering to a human in need thereof effective amounts of FTS (Farnesylthiosalicylic Acid), or various analogs thereof, or a pharmaceutically acceptable salt thereof, optionally in combination with a Bcr-Abl tyrosine kinase inhibitor. Also disclosed are pharmaceutical compositions comprising FTS, or various analogs thereof, or a pharmaceutically acceptable salt thereof, a Bcr-Abl tyrosine kinase inhibitor, preferably Imatinib and a pharmaceutically acceptable carrier.

L'invention concerne des méthodes pour traiter une malignité hématologique en administrant à un être humain le nécessitant des quantités efficaces de FTS (acide farnésyl thiosalicylique), ou plusieurs de ses analogues, ou un sel pharmaceutiquement acceptable de celui-ci, facultativement en combinaison avec un inhibiteur Bcr-Abl de la tyrosine kinase. L'invention concerne également des compositions pharmaceutiques qui comprennent le FTS, ou plusieurs analogues de celui-ci, ou un sel pharmaceutiquement acceptable de celui-ci, un inhibiteur Bcr-Abl de la tyrosine kinase, de préférence l'imatinib et un véhicule pharmaceutiquement acceptable.

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