Cyclohexylalanine derivatives as dipeptidyl peptidase-iv...

Details Cyclohexylalanine derivatives as dipeptidyl peptidase-iv... Cyclohexylalanine derivatives as dipeptidyl peptidase-iv...

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01)

Patent

CA 2564884

The present invention is directed to novel cyclohexylalanine derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme ("DP-IV inhibitors") and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase- IV enzyme is involved.

L'invention concerne des dérivés de la cyclohexylalanine qui sont des inhibiteurs de l'enzyme de la dipeptidyl peptidase-IV (<= inhibiteurs DP-IV") et qui sont utiles dans le traitement ou la prévention de maladies dans lesquelles l'enzyme de la dipeptidyl peptidase-IV est impliquée, telles que les diabètes et plus précisément les diabètes de type 2. L'invention concerne également des compositions pharmaceutiques renfermant ces composés et l'utilisation de ces composés et de ces compositions dans la prévention ou le traitement de telles maladies dans lesquelles l'enzyme de la dipeptidyl peptidase-IV est impliquée.

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