Diluent and method for determination of total calcium

Details Diluent and method for determination of total calcium Diluent and method for determination of total calcium

G - Physics

01

N

G01N 33/487 (2006.01) G01N 33/84 (2006.01)

Patent

CA 2073938

Diluents and methodologies for determining the concentration of total calcium in a clinical sample (e.g. whole blood, sera plasma urine cerebro spinal fluid) containing protein~bound calcium are disclosed. Methodologies include the steps of: (a) ad- mixing the sample with a diluent, the diluent including effective amounts of a pH buffer and at least two agents capable of com- plexing free calcium in the sample, where the agent-calcium complex association constants ("log K" in base 10) each have a range from about 1.5 to about 7.0; and (b) contacting an aliquot of the diluted sample with a calcium-specific ion selective elec- trode. The response of the calcium-specific ion selective electrode is an indication of the concentration of total calcium in the sample.

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