Methods and compositions for bactericide, bacteriostatic and...

A - Human Necessities – 61 – K

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Details

A61K 31/485 (2006.01) A61K 31/4748 (2006.01) A61P 17/02 (2006.01) A61P 17/10 (2006.01) A61P 29/00 (2006.01) A61P 31/04 (2006.01)

Patent

CA 2643277

The present invention relates to a method for providing bactericide or bacteriostatic, especially for treating disease due to bacterial infection. The method comprising administering a patient in need of such treatment a therapeutically effective amount of a compound of dextromethorphan or naloxone or a pharmaceutically acceptable salt or an analog thereof . The compound is applied to skin or mucosal surface of the patient. The invention also relates to a method of treating inflammation caused by suppressing secretion of TNF-.alpha., IL- .beta., or MCP-I from macrophage comprising administering a patient in need of such treatment a therapeutically effective amount of NADPH oxidase inhibitor.

La présente invention concerne une méthode de mise en AEuvre d'un traitement bactéricide ou bactériostatique, en particulier pour le traitement d'une maladie due à une infection bactérienne. La méthode comprend l'administration à un patient nécessitant un tel traitement d'une quantité thérapeutiquement active d'un dextrométhorphane ou d'une naloxone, ou d'un sel de qualité pharmaceutique ou d'un analogue dudit composé. Le composé est appliqué sur la peau ou la surface des muqueuses du patient. La présente invention concerne également une méthode de traitement de l'inflammation provoquée par l'inhibition de la sécrétion de TNF-.alpha., IL-.beta. ou MCP-I par les macrophages, ladite méthode comprenant l'administration à un patient nécessitant un tel traitement d'une quantité thérapeutiquement active d'un inhibiteur de NADPH oxydase.

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