Monoclonal antibody to human cardiac myoglobin

Details Monoclonal antibody to human cardiac myoglobin Monoclonal antibody to human cardiac myoglobin

C - Chemistry, Metallurgy

12

N

C12N 5/18 (2006.01) C07K 16/18 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2201153

A monoclonal antibody having high affinity to human cardiac myoglobin, which has undergone a conformational change resulting from the binding of the molecule to another molecule is described. This monoclonal antibody can be used in a rapid format double antibody immunoassay system to identif~y blood, serum or plasma levels of cardiac myoglobin. Such an immunoassay system can be used for diagnosing and quantifying myocardial necrosis and infarction.

L'invention concerne un anticorps monoclonal possédant une affinité élevée à l'égard de la myoglobine cardiaque humaine, laquelle a subi un changement de conformation résultant de la liaison de la molécule avec une autre molécule. On peut utiliser cet anticorps monoclonal dans un système d'immunodosage à double anticorps et à format rapide, destiné à identifier les taux de myoglobine cardiaque dans le sang, le sérum ou le plasma. On peut utiliser un tel système d'immunodosage pour diagnostiquer l'infarctus du myocarde et quantifier la nécrose myocardique.

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