Mutations in the bcr-abl tyrosine kinase associated with...

Details Mutations in the bcr-abl tyrosine kinase associated with... Mutations in the bcr-abl tyrosine kinase associated with...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C12Q 1/48 (2006.01) G01N 33/574 (2006.01) G01N 33/68 (2006.01) C07K 14/82 (2006.01) C40B 30/04 (2006.01)

Patent

CA 2450473

The invention described herein relates to novel genes and their encoded proteins, termed Mutants Associated withResistance to STI-571 (e.g.,T315I Bcr- Abl), and to diagnostic and therapeutic methods and compositions useful in the management of various cancers that express MARS. The invention further provides methods for identifying molecules that bind to and/or modulate the functional activity of MARS.

Cette invention concerne des nouveaux gènes et les protéines codées par ces gènes, dits <u>M</u>utants <u>A</u>ssociés à la <u>R</u>esistance à STI-571 (MARS) (tels que T315I Bcr-Abl), ainsi que des méthodes diagnostiques et thérapeutiques et des compositions convenant bien pour la prise en charge de divers cancers qui expriment MARS. De plus, l'invention concerne des méthodes d'identification de molécules qui se lient avec MARS ou qui en modulent l'activité fonctionnelle.

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