A pharmaceutical composition of tacrolimus

Details A pharmaceutical composition of tacrolimus A pharmaceutical composition of tacrolimus

A - Human Necessities

61

K

A61K 9/50 (2006.01) A61K 31/436 (2006.01)

Patent

CA 2683409

An oral tacrolimus composition comprises minicapsules having a core containing tacrolimus in a solubilised liquid form. The minicapsules have a release profile to release the pre-solubilised tacrolimus throughout the entire gastrointestinal tract. The composition may be used, for example, for treatment or prevention of solid organ transplant rejection.

L'invention concerne une composition orale de tacrolimus qui comprend des minicapsules qui possèdent un noyau contenant du tacrolimus sous forme liquide solubilisée. Les minicapsules présentent un profil de libération qui permet de libérer le tacrolimus pré-solubilisé dans l'ensemble du système gastro-intestinal. La composition peut être utilisée, par exemple, pour le traitement ou la prévention du rejet de greffe d'organes solides.

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