Human tissue inhibitor of metalloproteinase-4

Details Human tissue inhibitor of metalloproteinase-4 Human tissue inhibitor of metalloproteinase-4

C - Chemistry, Metallurgy

12

N

C12N 15/15 (2006.01) A61K 31/70 (2006.01) A61K 38/57 (2006.01) A61K 48/00 (2006.01) C07K 14/81 (2006.01) C07K 16/38 (2006.01) C12Q 1/37 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2206669

A human tissue inhibitor of metalloproteinases-4 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques. Also disclosed are methods for utilizing such polypeptide for the treatment of diseases, including arthritis and cancer. Antagonists against such polypeptides and their use as a therapeutic to resorb scar tissue are also disclosed. Diagnostic assays for detecting levels of human TIMP-4 protein and mutations in human TIMP-4 nucleic acid sequence are also disclosed.

L'invention porte sur des polypeptides humains inhibiteurs tissulaires de métalloprotéases-4 (TIMP-4) et de l'ADN (ARN) codant pour ces polypeptides ainsi qu'une procédure destinée à fabriquer ces polypeptides en utilisant des techniques de recombinaison. Elle comprend également des procédés qui permettent d'utiliser les polypeptides à des fins thérapeutiques pour le traitement de maladies, telles que l'arthrite et le cancer. Elle concerne également des antagonistes de ces polypeptides ainsi que leur emploi en tant qu'agent thérapeutique pour résorber le tissu cicatriciel. Elle comprend également des méthodes diagnostiques permettant de détecter les niveaux des protéines TIMP-4 humaines et les mutations de leurs séquences d'acides nucléiques.

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