Microfabricated sleeve devices for chemical reactions

B - Operations – Transporting – 01 – J

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B01J 19/24 (2006.01)

Patent

CA 2274620

A silicon-based sleeve type chemical reaction chamber (50) that combines doped silicon heating elements (57) and bulk silicon convective cooling elements (51, 52). A critical ratio of silicon and non- silicon based materials provides the thermal properties desired. The reaction chamber may be used for any chemical reaction, especially synthetic, thermal-cycling-based reactions such as the polymerase chain reaction (PCR) or ligase chain reaction.

Cette chambre de réacteur chimique du type gaine à base de silicium (50) associe des éléments chauffants dopés au silicium (57) et des éléments de refroidissement par convection à masse siliceuse (52, 52). Un rapport critique entre matériaux à base de silicium et matériaux dépourvus de silicium assure les propriétés thermiques désirées. Il est possible d'utiliser la chambre de réaction pour effectuer une réaction chimique, quelle qu'elle soit, notamment des réactions de synthèse, des réactions fondées sur un cyclage thermique, une amplification en chaîne par polymérase (ACP) ou une ligation répétitive d'oligonucléotides, par exemple.

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