N-substituted piperidines and their use as pharmaceuticals

Details N-substituted piperidines and their use as pharmaceuticals N-substituted piperidines and their use as pharmaceuticals

A - Human Necessities

61

K

A61K 31/445 (2006.01) A61K 31/451 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01) A61K 31/505 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2570637

The present invention relates to inhibitors of 11-.beta. hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-.beta. hydroxyl steroid dehydrogenase type I and/or diseases associated with aldosterone excess.

La présente invention concerne des inhibiteurs de la 11-ß hydroxystéroïde déshydrogénase de type 1, des antagonistes du récepteur des minéralocorticoïdes (MR), et des compositions pharmaceutiques de ces derniers. Les composés selon l'invention peuvent être utiles pour le traitement de diverses maladies associées à l'expression ou à l'activité de la 11-ß hydroxystéroïde déshydrogénase de type I et/ou de maladies associées à un excès d'aldostérone.

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