C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/06 (2006.01) A61K 31/4709 (2006.01) A61P 35/00 (2006.01) C07D 417/14 (2006.01)
Patent
CA 2579348
The present invention provides thiazoline substituted quinoline derivatives, where the quinoline ring is substituted at the 2 position, of formula (I) which derivatives demonstrate CDK1 antiproliferative activity and are therefore useful as anti-cancer agents, pharmaceutical compositions containing said compounds as well as processes for their manufacture.
La présente invention concerne des dérivés quinoline à substitution thiazoline représentés par la formule (I), le cycle quinoline étant substitué en position 2. Les dérivés selon l'invention présentent une activité s'opposant à la prolifération de CDK1 et servent par conséquent d'agents anti-cancéreux. L'invention concerne également des compositions pharmaceutiques contenant lesdits composés ainsi que des procédés de fabrication desdits composés.
Chen Li
Chen Shaoqing
Michoud Christophe
F.hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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