C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/55 (2006.01) A61K 31/44 (2006.01) A61K 31/4439 (2006.01) C07D 213/78 (2006.01) C07D 401/06 (2006.01) C07F 5/02 (2006.01)
Patent
CA 2659747
One aspect of the present invention relates to substituted pyridines and pharmaceutially acceptable salts thereof that are active against a range of mammalian maladies. Another aspect of the invention relates to a pharmaceutical composition, comprising a compound of the present invention or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable excipient. The present invention also relates to methods of treating a range of mammalian maladies or conditions, including but not limited to hyperlipidemia, hypercholesterolemia, atherosclerosis, coronary artery disease, congestive heart failure, cardiovascular disease, hypertension, coronary heart disease, angina, pellagra, Hartnup's syndrome, carcinoid syndrome, arterial occlusive disease, obesity, hypothyroidism, vasoconstriction, osteoarthritis, rheumatoid arthritis, diabetes, Alzheimer's disease, lipodystrophy, or dyslipidemia, raising serum high-density lipoprotein (HDL) levels, and lowering serum low-density lipoprotein (LDL) levels.
Un aspect de la présente invention concerne les pyridines substituées et leurs sels pharmaceutiquement acceptables, ayant une action dans le traitement de certaines maladies des mammifères. Un autre aspect de cette invention concerne une composition pharmaceutique comprenant un composé de la présente invention ou son sel pharmaceutiquement acceptable; et un excipient acceptable sur le plan pharmaceutique. La présente invention concerne également les procédés permettant de traiter certaines maladies des mammifères, y compris mais de façon non limitative, l'hyperlipémie, l'hypercholestérolémie, l'athérosclérose, l'artériopathie coronarienne, l'insuffisance cardiaque congestive, les maladies cardio-vasculaires, l'hypertension, les cardiopathies coronariennes, l'angine de poitrine, la pellagre, la maladie de Hartnup, le syndrome carcinoïde, l'artériopathie oblitérante, l'obésité, l'hypothyroïdie, les vasoconstrictions, l'arthrose, la polyarthrite rhumatoïde, le diabète, la maladie d'Alzheimer, la lipodystrophie, ou la dyslipidémie, en augmentant les niveaux de lipoprotéines de haute densité (HDL) et en diminuant les niveaux de lipoprotéines de basse densité (LDL) dans le sérum.
Bachovchin William W.
Lai Hung-Sen
Borden Ladner Gervais Llp
Trustees Of Tufts College
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